How RESO & STASE Work: The Science of Circadian Bio-Harmony

November 13, 2025

TL;DR

Your body works in two opposite phases: activation (morning/day) and restoration (evening/night). Supporting both with the same supplements at the same time is like hitting the gas and brake simultaneously: it doesn't work.

RESO (Morning/Day) - Activation Support:

Lion's Mane: Supports focus and mental clarity*
Cordyceps: Supports natural energy production (not borrowed via stimulants)*
ABM: Bridges cognitive and immune function*

STASE (Evening/Night) - Restoration Support:

Reishi: Supports nervous system downregulation and sleep quality*
Shiitake: Supports immune optimization during sleep*
Chaga: Provides antioxidant support for overnight cellular repair*

Why this matters: Taking activating mushrooms at night disrupts sleep. Taking calming mushrooms in the morning dampens your activation. Separation = proper support for each phase.

Timeline: Subtle effects week 1, noticeable shifts week 2-4, full integration by month 3. This isn't a quick fix, it's system-level restoration.

Read time: 18 minutes

Two Formulas, One System: Why Day and Night Matter

Here's a question we get asked constantly:

"Why do I need two different formulas? Why not just one mushroom blend I take all day?"

The answer reveals everything about how bio-harmony actually works and why most mushroom supplements miss the mark entirely.

Your body doesn't operate on a 24/7 schedule. It operates on circadian rhythms.

And trying to support both activation AND restoration with the same compounds at the same time is like trying to accelerate and brake simultaneously.

It doesn't work. And it's why you've been disappointed by (mushroom) supplements in the past.

Your Body's Two Phases

Your body has two primary nervous system states:

1. Sympathetic Activation (Morning/Day)

Cognitive engagement and focus
Energy mobilization
Stress resilience
Performance readiness
Immune surveillance

2. Parasympathetic Restoration (Evening/Night)

Nervous system downregulation
Cellular repair processes
Immune system optimization
Memory consolidation
Metabolic restoration

These aren't just different, they're opposite.

Modern life keeps you stuck in sympathetic activation:

Artificial light suppressing melatonin
Stimulants overriding natural fatigue
Screens activating stress responses
Constant notifications fragmenting attention
No clear transition between "on" and "off"

Result? You're in activation mode 18 hours a day, with only 6 hours of poor-quality sleep attempting to restore 18 hours of depletion.

Your body never fully activates OR fully restores. You exist in dysregulated middle-ground: wired but tired, exhausted but can't sleep, foggy but anxious.

Bio-harmony requires supporting BOTH phases properly:

Morning support should:

Enhance cognitive clarity and focus*
Support sustained energy production*
Optimize stress response capacity*
Maintain sympathetic activation WITHOUT overstimulation

Evening support should:

Facilitate parasympathetic shift*
Support cellular restoration processes*
Optimize immune function during sleep*
Enable nervous system downregulation WITHOUT sedation

One formula cannot do both. Biology doesn't work that way.

RESO: Morning Cognitive Activation

RESO is designed to support your body's natural morning activation; the shift from sleep into engaged, focused productivity.

Not stimulation. Activation.

The difference matters:

Stimulation: Forces performance through chemical override (caffeine, stimulants)
Activation: Supports your body's natural wake-up processes

Three mechanisms, one goal: Sustainable cognitive performance without override.

Mechanism #1: Lion's Mane - Neuroplasticity & Cognitive Clarity

Lion's Mane (Hericium erinaceus) is the most researched mushroom for cognitive function. Here's what makes it unique:

*Primary mechanism: Nerve Growth Factor (NGF) production support

NGF is a protein critical for:

Neuron growth and survival
Synaptic plasticity (your brain's ability to form new connections)
Myelin sheath maintenance (the insulation around nerve fibers)
Cognitive resilience and memory formation

Clinical research shows Lion's Mane may support:

Cognitive function in healthy adults*
Focus and concentration*
Mental clarity and processing speed*
Neuroprotective mechanisms*

Lion's Mane doesn't give you a caffeine-like jolt. It's subtle, then cumulative.

Week 1: You might not notice much. Some people report slightly clearer thinking or easier task-switching.

Week 2-4: Mental fog starts lifting. You finish work sessions and realize you stayed focused without forcing it. Words come more easily. Recall improves.

Month 2+: This becomes your new baseline. Cognitive clarity isn't something you chase, it's just there, available when you need it.

This is neuroplasticity support, not stimulant override. It takes time, but the results compound.

Mechanism #2: Cordyceps Militaris - Cellular Energy & Endurance

Cordyceps militaris is the gold standard for energy support—but not in the way most people think.

*Primary mechanism: Mitochondrial ATP production optimization

Your mitochondria are cellular power plants. They produce ATP (adenosine triphosphate), the energy currency your cells use for everything.

Cordyceps has been shown to:

Support ATP production efficiency*
Enhance oxygen utilization*
Improve exercise performance and endurance*
Support healthy cellular energy metabolism*

Here's the critical difference:

Stimulants (caffeine, etc.):

Borrow energy from your future self
Spike cortisol and adrenaline
Force cellular activity
Lead to crashes when effects wear off
Create tolerance and dependence

Cordyceps:

Supports your body's own energy production*
Works at the mitochondrial level
Provides sustained energy without crashes
No jitters, no tolerance, no dependency
Effects build over time as cellular function optimizes

Cordyceps became famous when Chinese Olympic runners broke multiple records and attributed their performance to Cordyceps supplementation.

Research has since validated its effects on:

VO2 max (oxygen utilization) improvement*
Exercise endurance and time to exhaustion*
Lactate threshold optimization*
Recovery time reduction*

But you don't need to be an athlete to benefit. *The same mechanisms that support athletic performance also support sustained cognitive and physical energy in daily life.

Cordyceps militaris (the species we use) is unique because it contains cordycepin: a bioactive compound not found in other Cordyceps species.

Cordycepin has been studied for:

Anti-inflammatory properties*
Cellular energy signaling*
Neuroprotective effects*
Immune system modulation*

RESO contains Cordyceps militaris extract, standardized for both polysaccharides cordycepin and adenosine content.

Mechanism #3: Agaricus Blazei Murill - Immune-Cognitive Bridge

Agaricus Blazei Murill (ABM) is less famous than Lion's Mane or Cordyceps, but its inclusion in RESO is strategic.

ABM is the immune-cognitive bridge.

*Primary mechanism: Immune modulation with cognitive benefits

Research shows ABM may support:

Immune system balance and modulation*
Healthy inflammatory response*
Stress resilience through HPA axis support*
Cognitive function during periods of stress*

Most people don't realize: Your immune system and cognitive function are intimately connected.

When your immune system is dysregulated:

Inflammatory cytokines affect brain function (brain fog, difficulty concentrating)
Chronic low-grade inflammation impairs cognition
Stress response becomes exaggerated
Energy gets diverted to immune activation instead of cognitive performance

*ABM helps maintain immune balance, which creates the foundation for cognitive clarity.

ABM has been studied for its effects on stress resilience:

Supporting healthy cortisol response*
Reducing perceived stress markers in research participants*
Maintaining cognitive performance during stressful periods*
Supporting emotional stability under pressure*

In RESO, ABM works synergistically with Lion's Mane and Cordyceps to:

Lion's Mane supports the cognitive hardware (neurons, synapses, plasticity)
Cordyceps provides the cellular energy
ABM maintains the immune-cognitive environment where both can work optimally

*Together, they create conditions for sustained, stress-resilient cognitive performance.

The RESO Synergy: Why These Three?

We didn't choose Lion's Mane, Cordyceps, and ABM because they're trendy. We chose them because their mechanisms work together.

The synergistic model:

1. Cognitive Foundation (Lion's Mane)

Supports neuroplasticity and cognitive clarity*
Provides the neural framework for focus

2. Energy Production (Cordyceps)

Fuels cognitive and physical performance*
Provides sustained ATP for cellular function

3. System Optimization (ABM)

Maintains immune balance for cognitive performance*
Buffers stress response for resilience

Take RESO daily in the morning and notice:

First week:

Subtle improvements in mental clarity
Slightly easier focus without forcing
Less dramatic afternoon energy dips
May not feel revolutionary yet; your cells are adapting

Weeks 2-6:

Morning fog consistently lighter
Sustained focus for 2-3 hour blocks without breaks
Natural energy that doesn't crash
Task-switching becomes easier
Caffeine cravings may reduce

Month 2+:

This becomes your baseline
Cognitive clarity is just... there
Energy feels stable throughout the day
Stress feels more manageable
Work output improves without increased effort

Key point: This isn't stimulation. This is optimization. You're not borrowing energy, you're producing it more efficiently.

STASE: Evening Nervous System Restoration

STASE is designed to support your body's natural evening transition: the shift from activation into restoration and repair.

Not sedation. Restoration.

The difference matters:

Sedation: Forces sleep through chemical knockout (Ambien, alcohol, even melatonin in high doses)
Restoration: Supports your body's natural parasympathetic shift and cellular repair processes

Three mechanisms, one goal: Deep nervous system regulation for restorative sleep and immune optimization.

Mechanism #1: Reishi - Nervous System Regulation & HPA Axis Balance

Reishi (Ganoderma lucidum) has been used in traditional medicine for over 2,000 years. Modern research is now validating why.

*Primary mechanism: HPA axis regulation and parasympathetic activation support

The HPA axis (Hypothalamic-Pituitary-Adrenal axis) is your stress response system. When it's dysregulated:

Cortisol stays elevated when it should drop
You feel "wired but tired"
Sleep quality suffers
Immune function declines

Reishi has been shown to support:

Healthy cortisol patterns (high morning, low evening)*
Parasympathetic nervous system activation*
Sleep quality and sleep architecture*
Stress resilience and emotional balance*

Reishi's calming effects come primarily from triterpenes: bioactive compounds unique to Reishi that have been studied for:

GABAergic system modulation (your primary calming neurotransmitter)*
Anti-anxiety effects without sedation*
Inflammatory response balance*
Neuroprotective properties*

Reishi doesn't knock you out. It helps your nervous system remember how to downregulate.

First week: You might notice slightly easier wind-down in the evening. Less ruminating thoughts. Subtle sense of calm.

Weeks 2-4: Sleep latency (time to fall asleep) may improve. Fewer middle-of-night wake-ups. Morning grogginess lessens.

Month 2+: Your nervous system starts naturally shifting into parasympathetic mode in the evening. You don't feel sedated; you feel genuinely calm. Sleep becomes restorative rather than just "time passed."

Mechanism #2: Shiitake - Immune Optimization During Sleep

Shiitake (Lentinula edodes) is one of the most studied culinary-medicinal mushrooms, with extensive research on immune system support.

*Primary mechanism: Immune modulation and restoration during sleep

Here's what most people don't know: Your immune system does its most important work while you sleep.

During deep sleep:

Immune cells proliferate and strengthen
Inflammatory response recalibrates
Cytokine production optimizes
Memory T-cells form and consolidate

Disrupted sleep = disrupted immunity. And vice versa: poor immune function disrupts sleep quality.

Shiitake contains a powerful beta-glucan polysaccharide called lentinan that has been extensively studied for:

Immune system modulation and balance*
Supporting natural killer cell activity*
Anti-inflammatory effects*
Antioxidant and protective properties*

Lentinan is so well-researched that it's been approved as an adjunct therapy in Japan for immune system support.

Shiitake's inclusion in STASE is strategic:

The immune-restoration cycle:

Your immune system rebuilds and recalibrates during sleep
Quality sleep = robust immune function
Immune dysregulation = disrupted sleep architecture
Shiitake supports the immune optimization that happens overnight*

The evening timing advantage:

Immune processes are most active during restoration phases
Beta-glucans work over hours, not minutes
Overnight = ideal window for immune system recalibration
Morning immune support can be activating (wrong phase)

*Shiitake works overnight while you sleep to support the immune restoration processes that need that specific window.

STASE contains Shiitake extract, providing high levels of lentinan and other immune-supportive compounds.

Mechanism #3: Chaga - Antioxidant Protection & Cellular Repair

Chaga (Inonotus obliquus) has the highest ORAC (Oxygen Radical Absorbance Capacity) score of any food or supplement ever tested.

*Primary mechanism: Antioxidant protection during cellular repair

Why antioxidants matter at night:

During the day, your cells accumulate oxidative stress from:

Metabolic processes
Environmental toxins
Blue light exposure
Inflammatory responses
Physical and cognitive activity

Sleep is when cellular repair happens. Your cells clear out damaged proteins, repair DNA, and restore function. But this repair process requires:

Antioxidant protection to neutralize free radicals
Raw materials for cellular building
Reduced oxidative stress load

*Chaga provides concentrated antioxidant support during this critical window.

Chaga is unique because it contains high levels of melanin; the same compound that gives human skin its color and provides UV protection.

Chaga's melanin content has been studied for:

Antioxidant and free radical scavenging effects*
Skin health support from within*
Cellular protection during stress*
DNA integrity support*

Chronic low-grade inflammation disrupts:

Sleep architecture (especially deep sleep stages)
Immune function
Cognitive performance the next day
Metabolic health

Chaga has been studied for its potential to:

Support healthy inflammatory response*
Modulate inflammatory cytokines*
Protect against oxidative damage*
Support cellular resilience*

STASE contains Chaga extract providing substantial antioxidant support during overnight restoration.

The STASE Synergy: Why These Three?

STASE combines three mechanisms that work together for comprehensive evening restoration:

1. Nervous System Downregulation (Reishi)

Shifts you into parasympathetic mode*
Supports healthy cortisol patterns*
Enables natural sleep initiation*

2. Immune Optimization (Shiitake)

Supports immune function during sleep*
Enhances gut-brain axis communication*
Optimizes immune cell activity overnight*

3. Cellular Protection (Chaga)

Provides antioxidant support during repair*
Reduces oxidative stress load*
Supports cellular restoration processes*

Together, they create the conditions for:

Natural nervous system downregulation
Deep, restorative sleep
Immune optimization
Cellular repair and protection
Metabolic restoration

Take STASE and notice:

First 2 weeks:

Evening wind-down feels slightly easier
You might notice less mental chatter before bed
Morning grogginess may begin to improve
Sleep tracking (if you use it) might show subtle improvements

Weeks 3-6:

Falling asleep becomes more consistent
Middle-of-night wake-ups may decrease
You wake feeling more genuinely rested
Afternoon energy improves (because nighttime restoration improved)
Stress feels more manageable

Month 2+:

Your nervous system naturally shifts into restoration mode in the evening
Sleep becomes predictably restorative
You wake up ready to engage, not needing to "force" yourself awake
Immune resilience improves (fewer colds, faster recovery)
This becomes your new normal

Key point: STASE doesn't sedate you. It supports your body's natural restoration processes. You're not knocked out, you're genuinely restored.

Why Day AND Night: The Complete System

Here's why most mushroom supplements fail:

They try to create one "do-everything" formula:

Contains 8-10 different mushrooms
Underdosed across the board (200mg each)
No circadian consideration
Taken at random times throughout the day

This doesn't work because:

None of the mushrooms reach therapeutic thresholds
Morning and evening needs are opposite
Some mushrooms are activating (wrong for evening)
Some mushrooms are calming (wrong for morning)
Timing matters as much as dosing

RESO + STASE work together as a complete circadian optimization system:

Morning (RESO):

Supports cognitive activation*
Enables sustained energy production*
Optimizes stress resilience*
Primes immune surveillance*

Evening (STASE):

Supports nervous system downregulation*
Enables cellular repair and restoration*
Optimizes immune function during sleep*
Prepares body for next day's activation*

The result: 24-hour bio-harmony. Your body learns to activate fully when it should, and restore fully when it should.

Not balance. Rhythm.

The Research Behind the Formulation

Every ingredient in RESO and STASE is backed by peer-reviewed clinical research:

Lion's Mane:

shown effective for cognitive support in multiple human trials*
NGF production support demonstrated in both animal and human studies*

Cordyceps militaris:

shown effective for ATP production and endurance*
VO2 max improvements in multiple exercise studies*

Agaricus Blazei Murill:

used in immune modulation studies*
Stress resilience effects documented in human trials*

Reishi:

shown effective for sleep quality and HPA axis support*
Triterpene content correlated with calming effects*

Shiitake:

used in immune modulation research*
polysaccharides extensively studied in clinical settings*

Chaga:

used in antioxidant and anti-inflammatory studies*
Highest ORAC score documented among natural substances*

RESO + STASE combined deliver dosing that matches or approaches these therapeutic thresholds.

Quality Standards: What You're Actually Getting

Every batch of RESO and STASE is:

✅ 100% fruiting body extracts (no mycelium, no grain)
✅ Hot water and+or Dual-extracted (hot water + alcohol) where it matters

✅ Third-party tested (Eurofins labs)

✅ Beta-glucan verified (enzymatic assay testing)
✅ Standardized to key actives (triterpenes for Reishi, cordycepin for Cordyceps, etc.)

✅ Live COA for every batch (verify immediately)

Extract ratios:

All mushrooms: 8:1 or higher
Means 8kg of whole fruiting bodies → 1kg of concentrated extract
Concentrates active compounds 8-fold
Higher bioavailability than raw powder

Minimum Beta-glucan content:

Lion's Mane: >40%
Cordyceps: >30% (>1% Cordycepin, >0.5% adenosine)
ABM: >35%
Reishi: >50% (plus standardized triterpenes)
Shiitake: >45%
Chaga: >35%

These are verified numbers from third-party testing (Eurofins), not marketing claims.

How to Use RESO & STASE

RESO:

Morning dose: 4 capsules upon waking (ideally one hour before food)
Don’t use with caffeïne or lactose
Do use with high quality water, natural organic fruit juice or organic green tea
Take with intention and combine with your morning ritual for maximum effect

STASE:

Evening dose 1: 4 capsules late afternoon/early evening (1 hour before bed)
Minimum 1 hour after food
Don’t use with caffeïne or lactose
Do use with high quality water, natural organic fruit juice
Take with intention and combine with your evening ritual for full nervous system regulation

Combined system: 4000mg therapeutic mushroom compounds daily.

Can I Take Them Together?

No, keep morning and evening formulas separate.

RESO contains activating compounds (Cordyceps, Lion's Mane) that you don't want in your system at bedtime.

STASE contains calming compounds (Reishi) that aren't optimal for morning activation.

The separation is the strategy. Different compounds, different timing, different mechanisms.

What to Expect: The Full Timeline

The 90-Day Integration

Days 1-7: The Subtle Shift

RESO: Slightly clearer thinking, minor energy improvements
STASE: Easier wind-down, subtle sleep improvements
May not feel dramatic; cells are adapting to therapeutic doses

Days 8-30: The Recognition

RESO: Noticeable focus improvements, stable energy, less afternoon crash
STASE: Faster sleep onset, deeper sleep, better morning energy
You start recognizing the difference when you miss a dose

Days 31-60: The Integration

RESO: Sustained focus is your new normal, cognitive clarity improves
STASE: Sleep architecture optimizes, immune resilience improves
Friends/partners may notice you seem more focused/rested

Days 61-90: The New Baseline

RESO: This level of cognitive performance feels natural, not forced
STASE: Deep restorative sleep is consistent, not random
You enter Bio-Harmony: your natural state where energy, focus and calmness are abundantly available to you.

Why 90 Days?

Real biological adaptation takes time:

Neuroplasticity (Lion's Mane): 30-60 days for new neural connections to strengthen
Mitochondrial adaptation (Cordyceps): 30-90 days for cellular energy optimization

HPA axis regulation (Reishi): 60-90 days for stress response recalibration

Immune modulation (Shiitake): 30-60 days for optimal effects
Cellular protection (Chaga): Ongoing, cumulative benefits

You're not taking a stimulant with immediate effects. You're supporting fundamental biological processes that need time to optimize.

Who RESO & STASE Are For

The Ideal User

RESO + STASE are designed for people who:

✅ Experience brain fog, difficulty focusing, or mental fatigue
✅ Feel wired-but-tired or struggle with energy crashes

✅ Have trouble falling asleep or wake unrefreshed

✅ Want sustainable performance without stimulant dependence
✅ Are tired of underdosed "wellness" products

✅ Value transparency and verified quality

✅ Understand that real results take time

✅ Are committed to 90 days minimum to evaluate properly

Who This Isn't For

RESO + STASE are NOT for people who:

❌ Want immediate stimulant-like effects
❌ Expect sleep aids that knock them out

❌ Won't commit to 60-90 days for proper evaluation

❌ Aren't willing to address lifestyle factors (chronic sleep deprivation, terrible diet)
❌ Want the cheapest possible option regardless of quality

❌ Expect supplements to override poor habits

Bio-harmony requires partnership with your body, not override.

Frequently Asked Questions

Q: Can I take RESO without STASE (or vice versa)?
A: Yes. Each formula works independently. But the full system (both) provides complete circadian optimization.

Q: Can I take RESO in the evening? A: Not recommended. Cordyceps and Lion's Mane support activation, opposite of what you want before bed.

Q: Will STASE make me drowsy during the day?
A: No. Reishi supports natural nervous system regulation, not sedation. Take the first dose 4-6 hours before bed for optimal timing.

Q: How long until I notice effects? A: Most people notice subtle improvements in 2-3 weeks. Full integration takes 60-90 days. Be patient, you're optimizing biology, not overriding it.

Q: Can I take these with coffee/caffeine?
A: There is no danger in taking these with caffeine, but caffeine decreases the bioavailability of mushroom extracts drastically. We advise to take our products at least one hour before or after caffeinated products. Many users of high quality mushroom extract find their caffeine needs decrease over time as natural energy improves.

Q: Are there any interactions or contraindications? A: Generally well-tolerated. If pregnant, nursing, or on medications (especially immunosuppressants or blood thinners), consult your healthcare provider first.

Q: What if I forget a dose?
A: Just take your next scheduled dose. Don't double up.

Q: Can I take more than the recommended dose? A: The recommended dosing matches clinical research. More isn't necessarily better. You are of course free to test what dosing works best for you.

The Bottom Line

RESO + STASE work because they:

✅ Use therapeutic doses (not marketing doses)

✅ Respect circadian biology (different support for different phases)

✅ Provide verified quality (third-party testing, not trust-me-bro claims)
✅ Support regulation (not override)

✅ Build sustainable capacity (not create dependency)

This isn't a quick fix. This is a daily practice of supporting your body's natural intelligence.

If you're ready to stop borrowing energy from tomorrow...
If you're tired of being wired-but-tired... If you want cognitive performance that's sustainable, not extractive...

This is how bio-harmony becomes real.

[See Our Scientific Library for more information on mushroom (extracts) →]

[See Third-Party Testing Results →]

[Start Your 90-Day Integration →]

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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