The Science
Your biology runs on rhythm.
Most supplements
ignore this.
Your biology runs on rhythm.
Most supplements ignore this.
We don't add more to your system. We work with the intelligence already inside it, at the precise biological moment it needs support.
73
Peer-reviewed studies
29
Human clinical trials
12
Studies from 2024–25
Explore the science
The problem
You're running an ancient nervous system in a modern world.
You're not broken. You're dysregulated.
Homo sapiens is 300,000 years old. Industrial life is 200. Digital life is 30. Our nervous systems were never designed for the pace, stimulation, and sleep deprivation of modern existence.
Chronic sympathetic overdrive, the biological "fight or flight" state, is no longer a survival response. For most high performers, it's the baseline. Cortisol that should peak at 7am stays elevated at midnight. Melatonin that should rise at 9pm is suppressed by screens. Sleep is shallow. Recovery is incomplete. The system never fully resets.
What you experience as burnout, brain fog, or wired-but-tired exhaustion has a precise biological explanation. And a precise biological solution if you work with your body's actual mechanisms, not against them.
"Coffee doesn't give you energy. It hides the signal that you're depleted until you crash. We built something different."
Most supplements operate like chemical sledgehammers. They force a single outcome through a single pathway and create dependency or adaptation in the process.
Functional mushrooms provide signalling molecules, containing information, that help your body make better regulatory decisions across multiple interconnected systems. They don't override, they support.
But only at research-backed doses. Only at the right circadian timing. And only when you understand the biology behind why they work.
Circadian biology
Your body operates on two opposite phases.
One formula cannot serve both.
Your body operates on two opposite phases.
One formula cannot serve both.
Every cell in your body runs on a 24-hour biological clock. This clock governs when each system activates, peaks, and restores. Modern life has broken the rhythm and most supplements only make it worse.
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6AM — 6PM · Activation Phase
Sympathetic State
Your biology shifts into high gear
Cortisol
Peaks at 8–9am · drives alertness and metabolism
Core Body Temp
Rises through morning · peaks at 4–6pm
Cognitive Performance
Working memory and focus peak mid-morning
Immune Surveillance
Active defence — detecting and responding to threats
ATP Demand
Cellular energy demand highest during active hours
24h Circadian Cycle
AM
PM
🌙
6PM — 6AM · Restoration Phase
Parasympathetic State
Your biology shifts into repair mode
Melatonin
Rises after 9pm · governs sleep onset and depth
Cortisol
Reaches its daily low around midnight · elevated evening cortisol disrupts sleep
Immune Rebuilding
NK cells, T-cells, cytokines peak during deep sleep
Cellular Repair
DNA repair, protein clearance, oxidative stress reset
Synaptic Repair
BDNF supports memory consolidation and neural maintenance during deep sleep
The modern dysregulation pattern
Most high performers are running sympathetic activation 18 hours a day, with only 6 hours of shallow sleep attempting to restore what 18 hours depleted. Cortisol stays elevated when it should be falling. Melatonin is suppressed by blue light. The nervous system never fully transitions between states. You end up stuck in between: wired but tired.
Our solution
The 24-Hour Bio-Harmony Protocol
Two formulas. Two phases. Compounds chosen specifically for the biological window they support.
Morning — Activation
RESO
Sympathetic Engagement · Cognitive Activation · 2,000mg
◆
Lion's Mane — 800mg
NGF stimulation · neuroplasticity · focus architecture
◆
Cordyceps — 667mg
ATP synthesis · mitochondrial activation · VO₂ support
◆
ABM — 533mg
Immune surveillance · HPA resilience · daytime defence
24-Hour
Bio-Harmony
Protocol
Evening — Restoration
STASE
Parasympathetic Shift · Cellular Repair · 2,000mg
◆
Reishi — 600mg
HPA axis support · calming pathway support · evening wind-down
◆
Chaga — 800mg
Ergothioneine · antioxidant support · cellular defense
◆
Shiitake — 600mg
Overnight immune support · gut-brain axis · beta-glucans
Your body needs different things at 8am and 10pm, so we split the system in two. Each formula groups mushrooms by the effects they're studied for. This is why the single-formula approach fails.
Five science pillars
The connected mechanisms
most supplements ignore
The mechanisms
most supplements ignore
Discover 5 pillars that are interconnected for true well-being and how our system was designed around that connection.
🌙
01
Circadian Rhythm
"Every mushroom supplement you've tried was fighting your biology."
Your body cycles through sympathetic activation (daytime) and parasympathetic restoration (night) governed by cortisol, melatonin, and circadian gene expression. Reishi's ganoderic acids align specifically with cortisol decline after 8pm. Lion's Mane NGF stimulation peaks during cognitive engagement hours.
Circadian timing shapes when cortisol, melatonin and immune activity rise and fall.
⚡
02
Sympathetic vs. Parasympathetic
"Your nervous system has two modes. Modern life jammed the switch to 'on'."
The autonomic nervous system governs every involuntary function in your body. Most high performers are running sympathetic activation 18 hours a day, with only 6 hours of compromised sleep attempting to restore what 18 hours depleted. Our system doesn't sedate. It helps the parasympathetic system do what it was designed to do.
Mitra 2024: Reishi supports stress reduction in athletes via triterpene pathways, confirmed in human RCT.
🧠
03
HPA Axis Regulation
"Most products chase how stress feels. We designed around the system behind it."
The hypothalamic-pituitary-adrenal axis is your body's stress command centre. Chronic overactivation dysregulates cortisol output, suppresses immune function, disrupts sleep, and degrades cognitive performance. Reishi triterpenes are studied for supporting a healthy stress response, without blocking it.
Mi 2022: Reishi ganoderic acids support HPA axis regulation
🔬
04
NGF & Neuroplasticity
"Coffee borrows focus from tomorrow. Lion's Mane builds the infrastructure that makes focus possible."
Stimulants block adenosine receptors, they mask the depletion signal until it overwhelms the override. Lion's Mane hericenones stimulate Nerve Growth Factor production in cell studies, the protein responsible for neuron growth, maintenance, and synaptic connectivity.
Kawagishi 1994–2012: hericenone-induced NGF stimulation in cell studies · Mori 2009: cognitive improvement in human RCT (fruiting body, 3g/day, 16 weeks) · Surendran 2025: acute cognitive enhancement in human RCT
⚙️
05
ATP Synthesis vs. Stimulation
"You're not tired because you need more caffeine. Your cells may not be producing energy as efficiently as they could."
In lab studies, Cordyceps militaris activates the AMPK, GLUT4, and PDH enzyme pathways. This is fundamentally different from stimulant-based energy: one supports metabolic capacity, the other borrows against it with interest. The crash is the debt repayment.
Hirsch 2016: VO₂ max improvements in a human trial of a cordyceps-containing mushroom blend · Choi 2020: ATP production via AMPK activation confirmed
Bioactive compounds
The molecules doing
the actual work
The molecules doing the actual work
The molecules doing
the actual work
Evidence tiers: Human RCT = confirmed in human clinical trials. Cell / Animal = mechanistic or pre-clinical evidence. All claims reflect what the cited studies actually show.
Beta-Glucans
All 6 mushrooms
Polysaccharides that bind to pattern recognition receptors on immune cells (Dectin-1, TLR-2), triggering coordinated immune activation. Support healthy inflammatory response, gut microbiome modulation, and cross-system communication via the gut-brain-immune axis.
Effective range: 250–1,000mg/day confirmed across 34 randomised controlled trials
Vlassopoulou 2021 · Zhong 2023 · Muroya 2025
Triterpenes
(Ganoderic Acids)
Reishi — STASE
Ganoderic acids support the GABAergic system, the brain's primary calming neurotransmitter pathway, and modulate the HPA axis. Align with natural cortisol decline in the evening, supporting parasympathetic shift without pharmacological sedation.
Stress reduction in human RCT (Mitra 2024) · GABAergic and HPA axis activity in animal studies.
Mi 2022 · Mitra 2024 · Gundermann 2025
Hericenones
Lion's Mane — RESO
Compounds isolated from Lion's Mane fruiting bodies documented to stimulate Nerve Growth Factor (NGF) secretion in cell studies. NGF governs neuron survival, axonal growth, and synaptic maintenance.
NGF stimulation in cell studies (Kawagishi 1994–2012)
Kawagishi 1994–2012
Cordycepin
Cordyceps — RESO
A nucleoside analogue that activates AMPK (the master metabolic regulator), upregulates GLUT4 glucose transporters, and activates PDH, the enzyme controlling ATP generation via the citric acid cycle. Cellular energy support, not receptor blocking
VO₂ max improvements confirmed in human exercise trial · ATP production mechanism via AMPK activation in lab studies
Hirsch 2016 · Choi 2020 · Chen 2007
Shiitake Beta-Glucans
Shiitake — STASE
Shiitake beta-glucans interact with immune cells in the gut. In a human trial, healthy adults eating shiitake daily for four weeks showed increased immune cell activity.
Immune markers improved in healthy adults (Dai 2015)
Dai 2015
Ergothioneine
& Polyphenols
Chaga — STASE
Chaga contains ergothioneine and polyphenols, antioxidant compounds studied for their role in cellular defense against oxidative stress during the overnight repair window.
Antioxidant activity documented in lab studies (Song 2014; Kou 2021)
Song 2014 · Kou 2021
Read our articles
How to Read a Mushroom Supplement COA: What the Numbers Actually Mean
March 12, 2026
Benjamin Van Doorslaer
The short answer: A Certificate of Analysis (COA) is a document from an independent lab verifying what's actually in a supplement. For mushroom products, the key numbers to check are:...
Functional Mushrooms for Perimenopause: What the Research Shows About Brain Fog, Sleep, and Energy
March 11, 2026
Benjamin Van Doorslaer
The short answer: Perimenopause disrupts sleep, cognitive function, stress resilience, and energy through hormonal shifts that directly affect your nervous system and brain chemistry. Functional mushrooms don't replace hormones, but...
What Happens When You Take Mushroom Supplements for 90 Days? One Person's Timeline
March 10, 2026
Benjamin Van Doorslaer
The short answer: One of our earliest users tracked her experience over three months of daily use with our morning and evening mushroom formulas. Focus and pattern recognition improved by...
Functional Mushrooms and Gut Health: What the Research Shows
March 9, 2026
Benjamin Van Doorslaer
The short answer: Functional mushrooms support gut health primarily through their polysaccharide content, which acts as a prebiotic, feeding beneficial bacteria and promoting short-chain fatty acid production. Research has shown...
Mushroom Supplements Buying Guide: Quality Checklist (What to Avoid and Why)
February 10, 2026
Benjamin Van Doorslaer
The short answer: Five things matter most: fruiting body source (not mycelium-on-grain), meaningful dose per mushroom (not a proprietary blend hiding low amounts), extraction method (dual extraction for species like...
Best Mushrooms for Brain Fog: Why Most Supplements Fail (And What Works)
February 3, 2026
Benjamin Van Doorslaer
The short answer: Lion's Mane is the most studied mushroom for brain fog, with research showing it stimulates nerve growth factor production and improves cognitive scores in human trials. But...
View all articles
73
Peer-reviewed studies in our research foundation
29
Human clinical trials
12
Published 2024–2025
7
Mushroom species covered
5
Mechanism categories
The vision
Regulation, not stimulation.
The supplement industry has taught a generation of high performers that the solution to depletion is more input. More caffeine. More stimulation of an already-overstimulated system. The result is dependency without capacity: borrowed energy that's never repaid.
What comes after that realisation is what we're building for. The conscious performer who wants clarity through regulation, not focus through force. That's what we are building towards.
When I discovered functional mushrooms in my own regulation journey, I was blown away by their adaptogenic, immune-modulating and nootropic properties. But finding high-quality mushroom products and understanding dosing, timing and synergy, was surprisingly difficult. That’s why my wife and I decided to create our own blends. It took us 2 years to create one of the most potent and pure mushroom systems; a powerful bridge between your natural intelligence and modern life.
"Your body already knows. We help it remember."
Benjamin & Evi - founders Wealth Alchemy
Take the next step
Ready to work with your biology,
not against it?
Start with the system including RESO and STASE, formulated to meet your ambitions without overriding yourself.
Evidence tiers reflect study design; cell and animal studies do not confirm effects in humans. All referenced research reflects findings from independent peer-reviewed literature.