The Science
Your biology runs on rhythm.
Most supplements
ignore this.
Your biology runs on rhythm.
Most supplements ignore this.
We don't add more to your system. We work with the intelligence already inside it, at the precise biological moment it needs support.
73
Peer-reviewed studies
29
Human clinical trials
12
Studies from 2024–25
Explore the science
The problem
You're not broken.
You're dysregulated.
You're not broken. You're dysregulated.
Homo sapiens is 300,000 years old. Industrial life is 200. Digital life is 30. Our nervous systems were never designed for the pace, stimulation, and sleep deprivation of modern existence.
Chronic sympathetic overdrive, the biological "fight or flight" state, is no longer a survival response. For most high performers, it's the baseline. Cortisol that should peak at 7am stays elevated at midnight. Melatonin that should rise at 9pm is suppressed by screens. Sleep is shallow. Recovery is incomplete. The system never fully resets.
What you experience as burnout, brain fog, or wired-but-tired exhaustion has a precise biological explanation. And a precise biological solution if you work with your body's actual mechanisms, not against them.
"Coffee doesn't give you energy. It hides the signal that you're depleted until you crash. We built something different."
Most supplements operate like chemical sledgehammers. They force a single outcome through a single pathway and create dependency or adaptation in the process.
Functional mushrooms provide signalling molecules, containing information, that help your body make better regulatory decisions across multiple interconnected systems. They don't override, they restore.
But only at research-backed doses. Only at the right circadian timing. And only when you understand the biology behind why they work.
Circadian biology
Your body operates on two opposite phases.
One formula cannot serve both.
Your body operates on two opposite phases.
One formula cannot serve both.
Every cell in your body runs on a 24-hour biological clock. This clock governs when each system activates, peaks, and restores. Modern life has broken the rhythm and most supplements only make it worse.
☀
6AM — 6PM · Activation Phase
Sympathetic State
Your biology shifts into high gear
Cortisol
Peaks at 8–9am · drives alertness and metabolism
Core Body Temp
Rises through morning · peaks at 4–6pm
Cognitive Performance
Working memory and focus peak mid-morning
Immune Surveillance
Active defence — detecting and responding to threats
ATP Demand
Cellular energy demand highest during active hours
24h Circadian Cycle
AM
PM
🌙
6PM — 6AM · Restoration Phase
Parasympathetic State
Your biology shifts into repair mode
Melatonin
Rises after 9pm · governs sleep onset and depth
Cortisol
Should drop to near-zero · high cortisol disrupts sleep
Immune Rebuilding
NK cells, T-cells, cytokines peak during deep sleep
Cellular Repair
DNA repair, protein clearance, oxidative stress reset
Synaptic Repair
BDNF supports memory consolidation and neural maintenance during deep sleep
The modern dysregulation pattern
Most high performers are running sympathetic activation 18 hours a day, with only 6 hours of shallow sleep attempting to restore what 18 hours depleted. Cortisol stays elevated when it should be falling. Melatonin is suppressed by blue light. The nervous system never fully transitions between states. You exist in dysregulated middle-ground: wired but tired.
Our solution
The 24-Hour Bio-Harmony Protocol
Two formulas. Two phases. Compounds chosen specifically for the biological window they support.
Morning — Activation
RESO
Sympathetic Engagement · Cognitive Activation · 2,000mg
◆
Lion's Mane — 800mg
NGF stimulation · neuroplasticity · focus architecture
◆
Cordyceps — 667mg
ATP synthesis · mitochondrial activation · VO₂ support
◆
ABM — 533mg
Immune surveillance · HPA resilience · daytime defence
24-Hour
Bio-Harmony
Protocol
Evening — Restoration
STASE
Parasympathetic Shift · Cellular Repair · 2,000mg
◆
Reishi — 600mg
HPA axis regulation · GABAergic support · cortisol decline alignment
◆
Chaga — 800mg
Ergothioneine antioxidant · anti-neuroinflammatory · cellular defence
◆
Shiitake — 600mg
Overnight immune optimisation · gut-brain axis · lentinan activity
Taking activating compounds at night disrupts parasympathetic wind-down. Taking restorative compounds in the morning dampens natural activation. This is why the single-formula approach fails.
Five science pillars
The mechanisms
most supplements ignore
The mechanisms
most supplements ignore
Each pillar is a distinct scientific argument. Together, they form a complete biological case for why Wealth Alchemy works and why everything you've tried before didn't.
🌙
01
Circadian Rhythm
"Every mushroom supplement you've tried was fighting your biology."
Your body cycles through sympathetic activation (daytime) and parasympathetic restoration (night) governed by cortisol, melatonin, and circadian gene expression. Reishi's ganoderic acids align specifically with cortisol decline after 8pm. Lion's Mane NGF stimulation peaks during cognitive engagement hours. Phase-specific dosing isn't a marketing angle — it's biology.
Circadian misalignment linked to immune suppression, cognitive decline, and metabolic dysfunction across 200+ published studies
⚡
02
Sympathetic vs. Parasympathetic
"Your nervous system has two modes. Modern life jammed the switch to 'on'."
The autonomic nervous system governs every involuntary function in your body. Most high performers are running sympathetic activation 18 hours a day — with only 6 hours of compromised sleep attempting to restore what 18 hours depleted. STASE doesn't sedate. It helps the parasympathetic system do what it was designed to do.
Mitra 2024: Reishi supports stress reduction in athletes via triterpene pathways — confirmed in human RCT · Gundermann 2025: Reishi + ashwagandha combination reduced perceived stress in 499-participant RCT
🧠
03
HPA Axis Regulation
"Most products treat stress symptoms. We address the system that creates them."
The hypothalamic-pituitary-adrenal axis is your body's stress command centre. Chronic overactivation dysregulates cortisol output, suppresses immune function, disrupts sleep, and degrades cognitive performance. Reishi triterpenes support HPA axis normalisation — restoring appropriate regulation without blocking the stress response itself.
Mi 2022: Reishi ganoderic acids support HPA axis regulation · direct cortisol modulation documented in peer-reviewed research
🔬
04
NGF & Neuroplasticity
"Coffee borrows focus from tomorrow. Lion's Mane builds the infrastructure that makes focus possible."
Stimulants block adenosine receptors, they mask the depletion signal until it overwhelms the override. Lion's Mane hericenones stimulate Nerve Growth Factor production in cell studies, the protein responsible for neuron growth, maintenance, and synaptic connectivity. A human RCT confirmed cognitive improvements after 16 weeks of supplementation. Construction, not borrowing.
Kawagishi 1994–2012: hericenone-induced NGF stimulation in cell studies · Mori 2009: cognitive improvement in human RCT (fruiting body, 3g/day, 16 weeks) · Surendran 2025: acute cognitive enhancement in human RCT
⚙️
05
ATP Synthesis vs. Stimulation
"You're not tired because you need more caffeine. Your cells may not be producing energy as efficiently as they could."
Cordyceps militaris activates the AMPK, GLUT4, and PDH enzyme pathways — the actual molecular machinery of ATP production. This is fundamentally different from stimulant-based energy: one restores metabolic capacity, the other borrows against it with interest. The crash is the debt repayment.
Hirsch 2016: VO₂ max improvements in human exercise trial · Choi 2020: ATP production via AMPK activation confirmed
Bioactive compounds
The molecules doing
the actual work
The molecules doing the actual work
The molecules doing
the actual work
Evidence tiers: Human RCT = confirmed in human clinical trials. Cell / Animal = mechanistic or pre-clinical evidence. All claims reflect what the cited studies actually show.
Beta-Glucans
All 6 mushrooms
Human RCT
Polysaccharides that bind to pattern recognition receptors on immune cells (Dectin-1, TLR-2), triggering coordinated immune activation. Support healthy inflammatory response, gut microbiome modulation, and cross-system communication via the gut-brain-immune axis.
Effective range: 250–1,000mg/day confirmed across 34 randomised controlled trials
Vlassopoulou 2021 · Zhong 2023 · Muroya 2025
Triterpenes
(Ganoderic Acids)
Reishi — STASE
Human RCT
Ganoderic acids support the GABAergic system, the brain's primary calming neurotransmitter pathway, and modulate the HPA axis. Align with natural cortisol decline in the evening, supporting parasympathetic shift without pharmacological sedation.
Stress reduction confirmed in human RCTs (Mitra 2024; Gundermann 2025 in combination with ashwagandha) · HPA axis modulation documented · peak efficacy aligned with evening cortisol decline
Mi 2022 · Mitra 2024 · Gundermann 2025
Hericenones
Lion's Mane — RESO
Cell / Animal
Human RCT
Compounds isolated from Lion's Mane fruiting bodies documented to stimulate Nerve Growth Factor (NGF) secretion in cell studies. NGF governs neuron survival, axonal growth, and synaptic maintenance. Human RCT (Mori 2009) confirmed cognitive improvements in mild cognitive impairment after 16 weeks of fruiting body supplementation.
NGF stimulation in cell studies (Kawagishi 1994–2012) · cognitive improvement in human RCT (Mori 2009) · acute cognitive enhancement in human RCT (Surendran 2025)
Mori 2009 · Kawagishi 1994–2012 · Spangenberg 2025
Cordycepin
Cordyceps — RESO
Human RCT
A nucleoside analogue that activates AMPK (the master metabolic regulator), upregulates GLUT4 glucose transporters, and activates PDH — the enzyme controlling ATP generation via the citric acid cycle. Clean, cellular energy production. No receptor blocking. No borrowed output. No crash.
VO₂ max improvements confirmed in human exercise trial · ATP production mechanism confirmed via AMPK activation
Hirsch 2016 · Choi 2020 · Chen 2007
Lentinan
Shiitake — STASE
Human RCT
A highly purified β-1,3-glucan shown to increase Natural Killer cell activity, T-lymphocyte proliferation, and cytokine production. So well-studied that purified lentinan is approved as an adjunct to standard cancer therapy in Japan and China, reflecting the depth of shiitake immune research.
Immune enhancement in healthy adults confirmed · T-lymphocyte production documented · purified lentinan approved as adjunct to chemotherapy in Japan
Dai 2015 · Xu 2015 · Bak 2014
Ergothioneine
& Polyphenols
Chaga — STASE
Cell / Animal
Chaga is one of the richest natural sources of ergothioneine, a unique antioxidant amino acid that accumulates in tissues under oxidative stress. Low plasma ergothioneine is directly associated with neurodegeneration and cognitive decline in human studies. Chaga's dense polyphenol matrix and anti-neuroinflammatory lanostanoid compounds support active antioxidant defence during the overnight cellular repair window.
Low ergothioneine linked to neurodegeneration (Wu 2021) · anti-neuroinflammatory activity confirmed (Kou 2021) · neuroprotective antioxidant activity documented
Song 2014 · Kou 2021 · Wu 2021 · Wu 2022
Read our articles
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The short answer: Lion's Mane is the most studied mushroom for brain fog, with research showing it stimulates nerve growth factor production and improves cognitive scores in human trials. But...
View all articles
73
Peer-reviewed studies in our research foundation
29
Human clinical trials
12
Published 2024–2025
7
Mushroom species covered
5
Mechanism categories
The vision
Regulation, not stimulation.
We are building a new category. Not functional mushrooms, that category already exists, and it's crowded with underdosed, mycelium-filled products sold by brands who refuse transparency.
We are building Bio-Harmony, the science and practice of returning your body's three core systems (cognitive, nervous, immune) to coherent, self-regulating function. Not peak performance. Not biohacking. Coherence.
"Your body already knows how to heal.
We help it remember."
The supplement industry has taught a generation of high performers that the solution to depletion is more input. More caffeine. More stimulation of an already-overstimulated system. The result is dependency without capacity: borrowed energy that's never repaid.
What comes after that realisation is what we're building for. The conscious performer who wants clarity through regulation, not focus through force. That's what we are building towards.
Take the next step
Ready to work with your biology,
not against it?
Start with the 24-Hour Bio-Harmony System including RESO and STASE, formulated for both phases of your circadian rhythm.
Evidence tiers reflect study design; cell and animal studies do not confirm effects in humans. All referenced research reflects findings from independent peer-reviewed literature.